sequence analysis servers and databases

  • BLAST - Choose from a variety of programs for comparing DNA or protein sequences to NCBI databases
  • COGnitor - Search for Clusters of Orthologous Groups (COGS) of proteins in a complete genome
  • DDBJ - DNA Data Bank of Japan
  • EcoCyc - Search the genome and biochemical pathways of E. coli
  • ExPASy Molecular Biology Server - Compare proteins to a variety of databases
  • KEGG - The Kyoto Encyclopedia of Genes and Genomes
  • MetaCyc - A general biochemical pathway database
  • PDB - Protein Data Bank
  • PIR - Protein Information Resource
  • Pfam - Compare a protein sequence to multiple alignments and Hidden Markov Models
  • Profile Scan (Motif Scan) - Search for motifs in a sequence using Prosite and Pfam
  • Prosite - Search the ExPASy database of protein families and domains
  • PSORT - Prediction of protein localization sites in amino acid sequences
  • SignalP - Search for signal peptide cleavage sites in protein sequences
  • Tandem Repeat Finder - Locate tandem repeats in a FASTA sequence
  • TMHMM - Prediction of transmembrane helices in proteins
  • Unfinished Microbial Genome Database - BLAST against genome sequences not yet in GenBank
  • Primer3 - Pick primers from a DNA sequence

 

 genome centers

  • ACGT - Bruce Roe's Advanced Center for Genome Technology at the University of Oklahoma Norman campus
  • CSHL - Cold Spring Harbor Laboratory in Cold Spring Harbor, NY
  • EBI - European Bioinformatics Institute in Cambridge, UK
  • LANL - Los Alamos National Laboratory in Los Alamos, NM
  • NCBI - National Center for Biotechnology Information
  • Sanger Centre - The Wellcome Trust Sanger Institute in Cambridge, UK
  • Stein Laboratory - Lincoln Stein's lab at CSHL
  • TIGR - The Institute for Genomic Research in Rockville, MD
  • GSC - Washington University Genome Sequencing Center in St. Louis

 

 software

  • *new* WinImp - Free data compression/extraction software
  • Artemis - DNA sequence viewer and annotation tool
  • Phred/Phrap/Consed - A base-caller, assembler, and graphical editor
  • TIGR software - Various tools for analysis of eukaryotic and prokaryotic organisms
  • Sanger software - A large collection of sequence analysis software

 

 other resources